NMII Forms a Contractile Transcellular Sarcomeric Network to Regulate Apical Cell Junctions and Tissue Geometry

@article{Ebrahim2013NMIIFA,
  title={NMII Forms a Contractile Transcellular Sarcomeric Network to Regulate Apical Cell Junctions and Tissue Geometry},
  author={Seham Ebrahim and Tomoki Fujita and Bryan A. Millis and Elliott D Kozin and Xuefei Ma and Sachiyo Kawamoto and Michelle A. Baird and Michael Davidson and Shigenobu Yonemura and Yasuo Hisa and Mary Anne Conti and Robert S Adelstein and Hirofumi Sakaguchi and Bechara Kachar},
  journal={Current Biology},
  year={2013},
  volume={23},
  pages={731-736}
}
Nonmuscle myosin II (NMII) is thought to be the master integrator of force within epithelial apical junctions, mediating epithelial tissue morphogenesis and tensional homeostasis. Mutations in NMII are associated with a number of diseases due to failures in cell-cell adhesion. However, the organization and the precise mechanism by which NMII generates and responds to tension along the intercellular junctional line are still not known. We discovered that periodic assemblies of bipolar NMII… CONTINUE READING