NMDA receptors mediate the behavioral effects of amphetamine infused into the nucleus accumbens

@article{Kelley1992NMDARM,
  title={NMDA receptors mediate the behavioral effects of amphetamine infused into the nucleus accumbens},
  author={Ann Elise Kelley and Laurie C. Throne},
  journal={Brain Research Bulletin},
  year={1992},
  volume={29},
  pages={247-254}
}
The present experiments examined glutamate-dopamine interactions within the nucleus accumbens in rats. It has been hypothesized that dopaminergic nerve terminals exert a modulatory influence on glutamate-mediated signals from corticolimbic areas. In the present studies, the effect of the selective NMDA (n-methyl-d-aspartate) antagonist AP5 (2-amino-5-phosphonopentanoic acid) on amphetamine-mediated behaviors was observed. In two behavioral paradigms, AP5 (0, 0.05, 0.5, 1.0 micrograms… CONTINUE READING
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