NMDA receptors mediate hypoxic spine loss in cultured neurons.

  title={NMDA receptors mediate hypoxic spine loss in cultured neurons.},
  author={M Joshua Hasbani and Natasha M Viquez and Mark P. Goldberg},
  volume={12 12},
We examined the pharmacology of dendritic morphologic changes in cultured cortical neurons exposed to sublethal oxygen-glucose deprivation (OGD). Confocal analysis of DiI-labeled neurons demonstrated transient dendritic swelling and spine loss after OGD. These morphological changes were reproduced by direct application of NMDA, kainate, veratridine, ionomycyin, and gramicidin, but not KCl. Blockade of voltage-gated sodium or calcium channels did not prevent OGD-induced dendritic spine loss. In… CONTINUE READING
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