NMDA receptors mediate background and excessive activity of gamma-motoneurones in the spinal cord.

  • Petar Polc
  • Published 1987 in European journal of pharmacology

Abstract

The effects of 3-((+/-)-2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP), a selective and potent antagonist of N-methyl-D-aspartic acid (NMDA) receptors, were studied on gamma-motoneurone activity in the spinal cord of unanaesthetized spinal cats. CPP (1-10 mg/kg i.v.) dose dependently reduced the spontaneous activity of gamma-motoneurones. The kainic acid (1 mg/kg i.v.)-induced bursting firing pattern of gamma-motoneurones was unaffected or enhanced by CPP. In contrast, CPP suppressed the increase of gamma-motoneuronal excitability caused by NMDA (3 mg/kg i.v.), suggesting that both the background and the exaggerated activity of gamma-motoneurones are mediated by an amino acid that activates NMDA receptors.

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@article{Polc1987NMDARM, title={NMDA receptors mediate background and excessive activity of gamma-motoneurones in the spinal cord.}, author={Petar Polc}, journal={European journal of pharmacology}, year={1987}, volume={144 1}, pages={113-5} }