NMDA receptors increase the size of GABAergic terminals and enhance GABA release.

@article{Fiszman2005NMDARI,
  title={NMDA receptors increase the size of GABAergic terminals and enhance GABA release.},
  author={M{\'o}nica L. Fiszman and Andrea Barberis and Congyi Lu and Zhanyan Fu and Ferenc Erd{\'e}lyi and G{\'a}bor Szab{\'o} and Stefano Vicini},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2005},
  volume={25 8},
  pages={2024-31}
}
In developing cerebellar interneurons, NMDA increases spontaneous GABA release by activating presynaptic NMDA receptors. We investigated the role of these receptors on differentiating basket/stellate cells in cerebellar cultures grown under conditions allowing functional synaptic transmission. Presynaptic GABAergic boutons were visualized either by GAD65 immunostaining or by using cells derived from GAD65-enhanced green fluorescent protein (eGFP) transgenic mice, in which cerebellar basket… CONTINUE READING

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