NMDA receptors in hippocampal GABAergic synapses and their role in nitric oxide signaling.

@article{Szabadits2011NMDARI,
  title={NMDA receptors in hippocampal GABAergic synapses and their role in nitric oxide signaling.},
  author={Eszter Szabadits and Csaba Cser{\'e}p and Andr{\'a}s Szőnyi and Yugo Fukazawa and Ryuichi Shigemoto and Masahiko Watanabe and Shigeyoshi Itohara and Tam{\'a}s F. Freund and Gabor Nyiri},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 16},
  pages={5893-904}
}
GABAergic inhibition plays a central role in the control of pyramidal cell ensemble activities; thus, any signaling mechanism that regulates inhibition is able to fine-tune network patterns. Here, we provide evidence that the retrograde nitric oxide (NO)-cGMP cascade triggered by NMDA receptor (NMDAR) activation plays a role in the control of hippocampal GABAergic transmission in mice. GABAergic synapses express neuronal nitric oxide synthase (nNOS) postsynaptically and NO receptors (NO… CONTINUE READING