NMDA receptors, place cells and hippocampal spatial memory

@article{Nakazawa2004NMDARP,
  title={NMDA receptors, place cells and hippocampal spatial memory},
  author={Kazu Nakazawa and Thomas J. McHugh and Matthew A. Wilson and Susumu Tonegawa},
  journal={Nature Reviews Neuroscience},
  year={2004},
  volume={5},
  pages={361-372}
}
N-methyl-D-aspartate receptors (NMDARs) in the rodent hippocampus have been shown to be essential for spatial learning and memory, and for the induction of long-term synaptic plasticity at various hippocampal synapses. In this review, we examine the evidence concerning the role of NMDARs in hippocampal memory processes, with an emphasis on the function of NMDARs in area CA1 of the hippocampus in memory acquisition, and the unique role of NMDARs in area CA3 in the rapid acquisition and… 
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References

SHOWING 1-10 OF 206 REFERENCES
Differential contribution of NMDA receptors in hippocampal subregions to spatial working memory
TLDR
Evidence is presented that NMDA receptors in CA3 are required in a situation in which spatial representation needs to be reorganized, whereas the NMDA receptor in CA1 and/or the dentate gyrus are more involved in acquiring memory that needs to been retrieved after a delay period exceeding a short-term range.
Formation of Temporal Memory Requires NMDA Receptors within CA1 Pyramidal Neurons
The Essential Role of Hippocampal CA1 NMDA Receptor–Dependent Synaptic Plasticity in Spatial Memory
Abolition of long-term stability of new hippocampal place cell maps by NMDA receptor blockade.
TLDR
The results suggest that the formation and short-term stability of firing fields in a new environment involve plasticity that is independent of NMDA receptor activation, and may be related to other NMDA-dependent processes such as long-term potentiation and spatial learning.
Requirement for Hippocampal CA3 NMDA Receptors in Associative Memory Recall
TLDR
Results provide direct evidence for CA3 NMDA receptor involvement in associative memory recall by generating and analyzing a genetically engineered mouse strain in which the N-methyl-d-asparate (NMDA) receptor gene is ablated specifically in the CA3 pyramidal cells of adult mice.
Hippocampal CA3 NMDA Receptors Are Crucial for Memory Acquisition of One-Time Experience
NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation.
TLDR
The data indicate that memory consolidation depends on the reactivation of the NMDA receptor, possibly to reinforce site-specific synaptic modifications to consolidate memory traces and serve as a cellular means by which the new memory is transferred from the hippocampus to the cortex for permanent storage.
Reversible neural inactivation reveals hippocampal participation in several memory processes
TLDR
It is indicated that hippocampal neural activity is necessary for both encoding and retrieval of spatial memory and for either trace consolidation or long-term storage.
Impaired Hippocampal Representation of Space in CA1-Specific NMDAR1 Knockout Mice
Hippocampus, theta, and spatial memory
  • J. O’Keefe
  • Biology, Psychology
    Current Opinion in Neurobiology
  • 1993
...
1
2
3
4
5
...