NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders

@article{Lau2007NMDART,
  title={NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders},
  author={Clifford G. Lau and R Suzanne Zukin},
  journal={Nature Reviews Neuroscience},
  year={2007},
  volume={8},
  pages={413-426}
}
The number and subunit composition of synaptic N-methyl-D-aspartate receptors (NMDARs) are not static, but change in a cell- and synapse-specific manner during development and in response to neuronal activity and sensory experience. Neuronal activity drives not only NMDAR synaptic targeting and incorporation, but also receptor retrieval, differential sorting into the endosomal–lysosomal pathway and lateral diffusion between synaptic and extrasynaptic sites. An emerging concept is that activity… CONTINUE READING
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