NMDA receptor subunits: diversity, development and disease

@article{CullCandy2001NMDARS,
  title={NMDA receptor subunits: diversity, development and disease},
  author={Stuart G. Cull-Candy and Stephen G Brickley and Mark Farrant},
  journal={Current Opinion in Neurobiology},
  year={2001},
  volume={11},
  pages={327-335}
}

Figures and Tables from this paper

Regulation of NMDA receptors by phosphorylation
Enhancing NMDA Receptor Function: Recent Progress on Allosteric Modulators
TLDR
This review will focus on enhancing NMDAR functions, especially on the recent progress in the generation of subunit-selective, allosteric positive modulators (PAMs) of N MDARs.
Influence of the NR3A subunit on NMDA receptor functions
Ontogeny of the N-methyl-D-aspartate (NMDA) receptor system and susceptibility to neurotoxicity.
TLDR
Findings indicate that if NMDA receptors are blocked during a specific period in neonatal life (first two weeks postnatally in the rat), massive apoptotic neurodegeneration results, due not to excitotoxic overstimulation of neurons but to deprivation of stimulation.
Molecular Properties and Cell Biology of the NMDA Receptor
NMDA receptors (NMDARs) play a distinct role at excitatory glutamatergic synapses, where they are usually localized with other ionotropic glutamate receptors, including tors. Two features are
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 109 REFERENCES
Fast NMDA Receptor–Mediated Synaptic Currents in Neurons From Mice Lacking the ε2 (NR2B) Subunit
TheN-methyl-d-aspartate (NMDA) receptor has been implicated in the formation of synaptic connections. To investigate the role of the e2 (NR2B) NMDA receptor subunit, which is prominently expressed ...
Changing subunit composition of heteromeric NMDA receptors during development of rat cortex
TLDR
Direct evidence is presented that NMDA receptors exist in rat neocortex as heteromeric complexes of considerable heterogeneity, some containing both NR2A and NR2B subunits.
NMDA-receptor channel diversity in the developing cerebellum
TLDR
Development changes in NMDA-receptor properties at the single-channel level are demonstrated, and it is suggested that in the cerebellum the expression of a specific subunit protein results in a distinct form of native receptor.
Differential expression of five N‐methyl‐D‐aspartate receptor subunit mRNAs in the cerebellum of developing and adult rats
TLDR
The expression patterns of mRNAs for the NMDA receptor subunits in the developing and adult rats by in situ hybridization were analyzed and developmental changes of the expression patterns were most salient in the cerebellum.
Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A
TLDR
The characterization of a regulatory NMDAR subunit, NR3A, is reported, which is expressed primarily during brain development and suggested to be involved in the development of synaptic elements by modulating N MDAR activity.
Subunit composition of N-methyl-D-aspartate receptors in the central nervous system that contain the NR2D subunit.
TLDR
The goal of the current study was to examine the subunit composition of native NMDA receptors that contain the NR2D subunit in the rat central nervous system by immunoprecipitation of assembledNMDA receptors from rat brain tissues using specific antibodies against NR1,NR2A, NR2B, and NR2 D subunits.
The glutamate receptor ion channels.
TLDR
The cloning of cDNAs encoding glutamate receptor subunits, which occurred mainly between 1989 and 1992, stimulated the development of ionotropic glutamate receptors in the brain.
...
1
2
3
4
5
...