NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation.

  title={NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation.},
  author={G Amadoro and Maria Teresa Ciotti and Marco Costanzi and Vincenzo Cestari and Pietro Calissano and Nadia Canu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 8},
The altered function and/or structure of tau protein is postulated to cause cell death in tauopathies and Alzheimer's disease. However, the mechanisms by which tau induces neuronal death remain unclear. Here we show that overexpression of human tau and of some of its N-terminal fragments in primary neuronal cultures leads to an N-methyl-D-aspartate receptor (NMDAR)-mediated and caspase-independent cell death. Death signaling likely originates from stimulation of extrasynaptic NR2B-subunit… CONTINUE READING


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