NMDA receptor-mediated currents are prominent in the thalamocortical synaptic response before maturation of inhibition.

@article{Agmon1992NMDARC,
  title={NMDA receptor-mediated currents are prominent in the thalamocortical synaptic response before maturation of inhibition.},
  author={Ariel Agmon and Diane K. O'Dowd},
  journal={Journal of neurophysiology},
  year={1992},
  volume={68 1},
  pages={
          345-9
        }
}
1. The N-methyl-D-aspartate subtype of glutamate receptor (NMDAR) is thought to underlie synaptic plasticity in both adult and developing CNS; however, its involvement in the thalamocortical synapse has not yet been directly demonstrated. 2. Whole-cell, thalamus-evoked synaptic currents were recorded from layer IV cells in slices of immature mouse somatosensory cortex. 3. Earlier than postnatal day 9 the majority of responses were monosynaptic and purely excitatory, with both non-NMDAR and… CONTINUE READING

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