NMDA receptor-mediated K+ efflux and neuronal apoptosis.

@article{Yu1999NMDARK,
  title={NMDA receptor-mediated K+ efflux and neuronal apoptosis.},
  author={Shan Ping Yu and C. H. Yeh and Ulrich Strasser and Meng. Tian and Dennis W. Choi},
  journal={Science},
  year={1999},
  volume={284 5412},
  pages={336-9}
}
Neuronal death induced by activating N-methyl-D-aspartate (NMDA) receptors has been linked to Ca2+ and Na+ influx through associated channels. Whole-cell recording from cultured mouse cortical neurons revealed a NMDA-evoked outward current, INMDA-K, carried by K+ efflux at membrane potentials positive to -86 millivolts. Cortical neurons exposed to NMDA in medium containing reduced Na+ and Ca2+ (as found in ischemic brain tissue) lost substantial intracellular K+ and underwent apoptosis. Both K… CONTINUE READING

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