NMDA receptor mechanisms contribute to neuroplasticity induced in caudalis nociceptive neurons by tooth pulp stimulation.

@article{Chiang1998NMDARM,
  title={NMDA receptor mechanisms contribute to neuroplasticity induced in caudalis nociceptive neurons by tooth pulp stimulation.},
  author={C. Chiang and S. J. Park and C. L. Kwan and J. Hu and B. Sessle},
  journal={Journal of neurophysiology},
  year={1998},
  volume={80 5},
  pages={
          2621-31
        }
}
We recently demonstrated that application of mustard oil (MO), a small-fiber excitant and inflammatory irritant, to the rat maxillary molar tooth pulp induces significant and prolonged increases in jaw muscle electromyographic (EMG) activity that are suggestive of central neuroplasticity. Because small-fiber afferents, including pulp afferents, access nociceptive neurons in trigeminal (V) subnucleus caudalis, this study examined whether pulpal application of MO induces neuroplastic changes in… Expand
Neuroplasticity induced by tooth pulp stimulation in trigeminal subnucleus oralis involves NMDA receptor mechanisms.
TLDR
It is indicated that the application of MO to the tooth pulp can induce significant neuroplastic changes in oralis nociceptive neurons and that central NMDA receptor mechanisms may be involved in these neuroPlastic changes. Expand
Central sensitization in thalamic nociceptive neurons induced by mustard oil application to rat molar tooth pulp
TLDR
Application of the inflammatory irritant MO to the tooth pulp results in central sensitization of thalamic nociceptive neurons and this neuronal hyperexcitability likely contributes to the behavioral consequences of peripheral inflammation manifesting as pain referral, hyperalgesia and allodynia. Expand
Central sensitization of nociceptive neurons in trigeminal subnucleus oralis depends on integrity of subnucleus caudalis.
TLDR
Findings indicate that inflammatory pulp-induced central sensitization in Vo is dependent on the functional integrity of Vc, and MO-induced neuroplastic changes in Vo are dependent on an ascending influence from Vc. Expand
Central sensitization induced in thalamic nociceptive neurons by tooth pulp stimulation is dependent on the functional integrity of trigeminal brainstem subnucleus caudalis but not subnucleus oralis
TLDR
Findings indicate that central sensitization induced in nociceptive neurons within VPM and PO by noxious stimulation of the tooth pulp is dependent upon the functional integrity of Vc but not Vo. Expand
Endogenous ATP involvement in mustard-oil-induced central sensitization in trigeminal subnucleus caudalis (medullary dorsal horn).
TLDR
The findings implicate endogenous ATP as an important mediator contributing to the development of central sensitization in nociceptive neurons of the deep laminae of the dorsal horn. Expand
Purinergic receptors are involved in tooth-pulp evoked nocifensive behavior and brainstem neuronal activity
TLDR
The present findings suggest that activation of P2X3 and P2x2/3 receptors in the tooth pulp is sufficient to elicit nociceptive behavioral responses and trigeminal brainstem neuronal activity. Expand
Involvement of glia in central sensitization in trigeminal subnucleus caudalis (medullary dorsal horn)
TLDR
The results suggest that glial metabolic processes are important in the development of Vc central sensitization, and that inhibition of spinal astroglial metabolism or spinal microglial p38MAPK activation can attenuate hyperalgesia in inflammatory pain models. Expand
Somatostatin enhances tooth-pulp-evoked cervical dorsal horn neuronal activity in the rat via inhibition of GABAergic interneurons
TLDR
Results suggest that a local release of SST facilitates the excitability of trigeminal nocicepitve C1 neuronal activity via inhibition of GABAergic neurons, a potential therapeutic target in the treatment of trigEMinal pain, including hyperalgesia. Expand
Effects of GABA receptor antagonist on trigeminal caudalis nociceptive neurons in normal and neonatally capsaicin-treated rats.
TLDR
The results suggest that GABA(A) receptor-mediated inhibition may be involved in maintaining the functional expression of Vc nociceptive neuronal properties in normal conditions, and that in animals depleted of their C-fiber afferents, some features of this neurons' modulation may be disrupted such that a neurons' excitation is manifested. Expand
Striatal inhibition of nociceptive responses evoked in trigeminal sensory neurons by tooth pulp stimulation.
TLDR
The results indicate that the striatum could be involved in the modulation of nociceptive inputs and confirm the role of the basal ganglia in the processing of nOCiceptive information. Expand
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