NMDA receptor expression and roles in human articular chondrocyte mechanotransduction.

@article{Salter2004NMDARE,
  title={NMDA receptor expression and roles in human articular chondrocyte mechanotransduction.},
  author={Donald Salter and Malcolm O Wright and Sarah J. Millward-Sadler},
  journal={Biorheology},
  year={2004},
  volume={41 3-4},
  pages={273-81}
}
Mechanical forces influence articular cartilage structure by regulating chondrocyte activity. Mechanical stimulation results in activation of an alpha5beta1 integrin dependent intracellular signal cascade involving focal adhesion kinase and protein kinase C, triggering the release of interleukin-4 from the cell. In normal HAC the response to physiological mechanical stimulation is characterised by increased levels of aggrecan mRNA and a decrease in levels of mRNA for matrix metalloproteinase 3… CONTINUE READING
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