NMDA receptor clustering in rat prefrontal cortex revealed by in vitro calcium macroimaging

  title={NMDA receptor clustering in rat prefrontal cortex revealed by in vitro calcium macroimaging},
  author={M. Takita and H. Yokoi and T. Mizuno},
  • M. Takita, H. Yokoi, T. Mizuno
  • Published 1997
  • Chemistry, Medicine
  • NeuroReport
  • LIVING coronal brain slices were prepared from the rat prefrontal cortex (pFC) to determine the topographical distribution of the functional calcium-permeable N-methyl-D-aspartate (NMDA) receptor in vitro using calcium macroimage analysis with fura-2 AM. NMDA (0.25, 0.5, 1 or 2 × 10−4 M for 30 s) bath application showed a dose-dependent [Ca2+]i increase from the steady-state level in several portions selected from the whole hemisphere slice. This regional response was suppressed by D-2-amino-5… CONTINUE READING
    11 Citations
    NMDA Receptor Function in the Prefrontal Cortex of a Rat Model for Attention-Deficit Hyperactivity Disorder
    • 51
    Induction of stable long‐term depression in vivo in the hippocampal–prefrontal cortex pathway
    • 100
    The role of NMDA receptors in the pigeon prefrontal cortex (Nidopallium caudolaterale)
    • PDF
    Why is methylphenidate effective in ADHD
    • 1


    Synaptic plasticity: molecular cellular, and memory
    • 1993
    Dopamine pathways in the rat brain
    • Horn AS, Korf J and Westerink BHC, eds. The Neurobiology of Dopamine
    • 1979
    Tokyo University of Pharmacy and Life Science) for their invaluable advice on experimental techniques. This work was supported in part by a 1995 Japanese supplement
    • Brain Res
    • 1974