NMDA receptor clustering in rat prefrontal cortex revealed by in vitro calcium macroimaging

@article{Takita1997NMDARC,
  title={NMDA receptor clustering in rat prefrontal cortex revealed by in vitro calcium macroimaging},
  author={M. Takita and H. Yokoi and T. Mizuno},
  journal={NeuroReport},
  year={1997},
  volume={8},
  pages={551–553}
}
  • M. Takita, H. Yokoi, T. Mizuno
  • Published 1997
  • Chemistry, Medicine
  • NeuroReport
  • LIVING coronal brain slices were prepared from the rat prefrontal cortex (pFC) to determine the topographical distribution of the functional calcium-permeable N-methyl-D-aspartate (NMDA) receptor in vitro using calcium macroimage analysis with fura-2 AM. NMDA (0.25, 0.5, 1 or 2 × 10−4 M for 30 s) bath application showed a dose-dependent [Ca2+]i increase from the steady-state level in several portions selected from the whole hemisphere slice. This regional response was suppressed by D-2-amino-5… CONTINUE READING
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