NMDA receptor blockade prevents the increase in protein kinase C substrate (protein F1) phosphorylation produced by long-term potentiation.

@article{Linden1988NMDARB,
  title={NMDA receptor blockade prevents the increase in protein kinase C substrate (protein F1) phosphorylation produced by long-term potentiation.},
  author={David E. J. Linden and Ka Leung Wong and F S Sheu and Aryeh Routtenberg},
  journal={Brain research},
  year={1988},
  volume={458 1},
  pages={142-6}
}
Recent evidence has implicated activation of the N-methyl-D-aspartate (NMDA) class of glutamate receptor in the initiation of hippocampal long-term potentiation (LTP), an electrophysiological model of information storage in the brain. A separate line of evidence has suggested that activation of protein kinase C (PKC) and the consequent phosphorylation of its substrates is necessary for the maintenance of the LTP response. To determine if PKC activation is a consequence of NMDA receptor… CONTINUE READING

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Recent evidence has implicated activation of the N - methyl - D - aspartate ( NMDA ) class of glutamate receptor in the initiation of hippocampal long - term potentiation ( LTP ) , an electrophysiological model of information storage in the brain .
Recent evidence has implicated activation of the N - methyl - D - aspartate ( NMDA ) class of glutamate receptor in the initiation of hippocampal long - term potentiation ( LTP ) , an electrophysiological model of information storage in the brain .
Recent evidence has implicated activation of the N - methyl - D - aspartate ( NMDA ) class of glutamate receptor in the initiation of hippocampal long - term potentiation ( LTP ) , an electrophysiological model of information storage in the brain .
Recent evidence has implicated activation of the N - methyl - D - aspartate ( NMDA ) class of glutamate receptor in the initiation of hippocampal long - term potentiation ( LTP ) , an electrophysiological model of information storage in the brain .
Recent evidence has implicated activation of the N - methyl - D - aspartate ( NMDA ) class of glutamate receptor in the initiation of hippocampal long - term potentiation ( LTP ) , an electrophysiological model of information storage in the brain .
Recent evidence has implicated activation of the N - methyl - D - aspartate ( NMDA ) class of glutamate receptor in the initiation of hippocampal long - term potentiation ( LTP ) , an electrophysiological model of information storage in the brain .
To determine if PKC activation is a consequence of NMDA receptor activation during LTP , we applied the NMDA receptor antagonist drug , DL - aminophosphonovalerate ( APV ) both immediately prior to and following high frequency stimulation , resulting in successful and unsuccessful blockade of LTP initiation , respectively .
To determine if PKC activation is a consequence of NMDA receptor activation during LTP , we applied the NMDA receptor antagonist drug , DL - aminophosphonovalerate ( APV ) both immediately prior to and following high frequency stimulation , resulting in successful and unsuccessful blockade of LTP initiation , respectively .
To determine if PKC activation is a consequence of NMDA receptor activation during LTP , we applied the NMDA receptor antagonist drug , DL - aminophosphonovalerate ( APV ) both immediately prior to and following high frequency stimulation , resulting in successful and unsuccessful blockade of LTP initiation , respectively .
To determine if PKC activation is a consequence of NMDA receptor activation during LTP , we applied the NMDA receptor antagonist drug , DL - aminophosphonovalerate ( APV ) both immediately prior to and following high frequency stimulation , resulting in successful and unsuccessful blockade of LTP initiation , respectively .
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