NMDA-receptor antibody and anti-Hu antibody positive paraneoplastic syndrome associated with a primary mediastinal seminoma

  title={NMDA-receptor antibody and anti-Hu antibody positive paraneoplastic syndrome associated with a primary mediastinal seminoma},
  author={Inga Pohley and K. M. Roesler and Matthias Wittstock and Andreas Bitsch and Reiner Benecke and Alexander Wolters},
  journal={Acta Neurologica Belgica},
Paraneoplastic neurological syndromes (PNS) are mostly immune-mediated, tumor-associated disorders that can develop years before detection of any malignancy. Their prevalence varies among different tumor types. Diagnostic criteria for PNS include the presence of a classical or nonclassical clinical syndrome in association with antineuronal antibodies and the presence of any malignancy [1]. We report the case of a 32-year-old male, who presented with a 2-year history of progressing neurological… 
Bilateral Vocal Cord Paralysis and Cervicolumbar Radiculopathy as the Presenting Paraneoplastic Manifestations of Small Cell Lung Cancer: A Case Report and Literature Review
A 58-year-old female presenting to an Otolaryngology clinic with a history of progressive hoarseness and dysphagia is presented, the second reported case of BVCP as a presenting symptom of paraneoplastic syndrome secondary to small cell lung cancer.
Encephalomyeloneuropathy with CRMP-5 antibodies in a patient with a primary mediastinal serinoma
A 23-year-old nonsmoking man presented with difficulty walking, numbness, and weakness progressing over several months, and exhibited significant dysmetria in both upper and lower extremities.
Peripheral neuropathy in limbic encephalitis with anti‐glutamate receptor antibodies: Case report and systematic literature review
Autoantibodies to the alpha‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor and N‐methyl‐d‐aspartate (NMDA) receptor are known to be the causes of autoimmune encephalitis


Paraneoplastic syndromes of the CNS
Recommended diagnostic criteria for paraneoplastic neurological syndromes
An international panel of neurologists interested in PNS recommended new criteria for those in whom no clinical consensus was reached in the past and defined “classical” syndrome and onconeural antibody as “well characterised”.
Primary Mediastinal “Thymic” Seminomas
The emphasis in this manuscript will be to highlight the occurrence and overall characteristics of one of the most common GCTs in the mediastinal region—seminoma.
Acta Neurol Belg
  • Acta Neurol Belg
  • 2015
a severe, multistage, treatable Fig
  • 1 On the left Cerebral MRI (1.5 T) showing an axial T2-FLAIR-sequence with a hyperintense, non-contrast enhancing signal alteration of the right hippocampus region (arrows). On the right Axial thorax-CT (16-slice system) showing a non-contrast enhancing mass with a diameter of 2 cm (arrows) in the u
  • 2015
Primary mediastinal ‘‘thymic’
  • seminomas. Adv Anat Pathol 19(2):75–80
  • 2012