NMDA receptor antagonists inhibit opiate antinociceptive tolerance and locomotor sensitization in rats

Abstract

N-Methyl-d-aspartate (NMDA) receptors have an important role in different forms of behavioral and neural plasticity. Evidence suggests that these receptors may also be involved in plasticity arising from long-term treatment with different drugs of abuse, including tolerance, sensitization, and physical dependence. There is abundant evidence demonstrating… (More)
DOI: 10.1007/s00213-007-0984-8

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