NMDA receptor antagonists inhibit opiate antinociceptive tolerance and locomotor sensitization in rats

@article{Mndez2007NMDARA,
  title={NMDA receptor antagonists inhibit opiate antinociceptive tolerance and locomotor sensitization in rats},
  author={I. A. Guzm{\'a}n M{\'e}ndez and Keith A. Trujillo},
  journal={Psychopharmacology},
  year={2007},
  volume={196},
  pages={497-509}
}
N-Methyl-d-aspartate (NMDA) receptors have an important role in different forms of behavioral and neural plasticity. Evidence suggests that these receptors may also be involved in plasticity arising from long-term treatment with different drugs of abuse, including tolerance, sensitization, and physical dependence. There is abundant evidence demonstrating that NMDA receptors are involved in tolerance to opiate-induced antinociception; however, the role of these receptors in sensitization to the… CONTINUE READING

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