NMDA receptor antagonists augment antidepressant-like effects of lithium in the mouse forced swimming test

@article{Ghasemi2010NMDARA,
  title={NMDA receptor antagonists augment antidepressant-like effects of lithium in the mouse forced swimming test},
  author={Maryam Ghasemi and Mohsin Raza and Ahmad Reza Dehpour},
  journal={Journal of Psychopharmacology},
  year={2010},
  volume={24},
  pages={585 - 594}
}
Although there is evidence of the involvement of N-methyl-D-aspartate receptors (NMDAR) in the action of lithium, its role in the antidepressant effects of lithium in a behavioural model remains unclear. In this study, we evaluated the effects of NMDAR antagonists on the antidepressant-like effects of lithium in the mouse forced swimming test. Lithium (30 and 100 mg/kg, i.p.) significantly (P < 0.01) reduced the immobility times of mice, whereas at lower doses (5 and 10 mg/kg) had no effect… 

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References

SHOWING 1-10 OF 118 REFERENCES
NMDA/glutamate mechanism of antidepressant-like action of magnesium in forced swim test in mice
Antidepressant activity of non-competitive and competitive NMDA receptor antagonists in a chronic mild stress model of depression.
Additive effects of lithium and antidepressants in the forced swimming test: further evidence for involvement of the serotoninergic system
TLDR
The hypothesis that the potentiation by lithium of ADS is via direct 5HT mechanisms, indirect via a NA/5HT link, and/or by second messenger systems is supported.
...
...