NMDA receptor antagonists augment antidepressant-like effects of lithium in the mouse forced swimming test
@article{Ghasemi2010NMDARA, title={NMDA receptor antagonists augment antidepressant-like effects of lithium in the mouse forced swimming test}, author={Maryam Ghasemi and Mohsin Raza and Ahmad Reza Dehpour}, journal={Journal of Psychopharmacology}, year={2010}, volume={24}, pages={585 - 594} }
Although there is evidence of the involvement of N-methyl-D-aspartate receptors (NMDAR) in the action of lithium, its role in the antidepressant effects of lithium in a behavioural model remains unclear. In this study, we evaluated the effects of NMDAR antagonists on the antidepressant-like effects of lithium in the mouse forced swimming test. Lithium (30 and 100 mg/kg, i.p.) significantly (P < 0.01) reduced the immobility times of mice, whereas at lower doses (5 and 10 mg/kg) had no effect…
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