NMDA receptor antagonism: escalation of aggressive behavior in alcohol-drinking mice

@article{Newman2012NMDARA,
  title={NMDA receptor antagonism: escalation of aggressive behavior in alcohol-drinking mice},
  author={Emily L. Newman and Adam Chu and Brittany Baham{\'o}n and Aki Takahashi and Joseph F Debold and Klaus A Miczek},
  journal={Psychopharmacology},
  year={2012},
  volume={224},
  pages={167-177}
}
Memantine is a potential treatment for alcoholic patients, yet few studies investigate the effect of concurrent treatment with memantine and ethanol on aggression. We evaluated aggressive behavior following ethanol consumption and treatment with glutamatergic drugs to characterize interactions between these compounds. This study aimed to use rodent models of aggression to examine interactions between glutamatergic compounds and ethanol. Once male CFW mice reliably self-administered 1 g/kg… CONTINUE READING