NMDA receptor activation mediates the loss of GABAergic inhibition induced by recurrent seizures.

Abstract

Previously we have shown that delivery of rapidly recurring hippocampal seizures (RRHS) to awake rats causes a rapid kindling and that RRHS in urethane-anesthetized rats leads to a progressive lengthening of afterdischarges and diminution of paired pulse inhibition. The present experiments examined the relationship between the changes in afterdischarge… (More)

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@article{Kapur1990NMDARA, title={NMDA receptor activation mediates the loss of GABAergic inhibition induced by recurrent seizures.}, author={Jaideep Kapur and Eric W. Lothman}, journal={Epilepsy research}, year={1990}, volume={5 2}, pages={103-11} }