NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones

@article{Macdermott1986NMDAreceptorAI,
  title={NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones},
  author={Amy B Macdermott and Mark L Mayer and Gary L Westbrook and Stephen M Smith and Jeffery L. Barker},
  journal={Nature},
  year={1986},
  volume={321},
  pages={519-522}
}
Excitatory amino acids act via receptor subtypes in the mammalian central nervous system (CNS)1–3. The receptor selectively activated by N-methyl-D-aspartic acid (NMDA) has been best characterized using voltage-clamp and single-channel recording; the results suggest that NMDA receptors gate channels that are permeable to Na+, K+ and other monovalent cations4–7. Various experiments suggest that Ca2+ flux is also associated with the activation of excitatory amino-acid receptors on vertebrate… CONTINUE READING
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