NMDA-induced neuroprotection in hippocampal neurons is mediated through the protein kinase A and CREB (cAMP-response element-binding protein) pathway

@article{Valera2008NMDAinducedNI,
  title={NMDA-induced neuroprotection in hippocampal neurons is mediated through the protein kinase A and CREB (cAMP-response element-binding protein) pathway},
  author={Elvira Valera and Francisco Javier S{\'a}nchez-Mart{\'i}n and Antonio V. Ferrer-Montiel and {\'A}ngel Messeguer and J. Montada Merino},
  journal={Neurochemistry International},
  year={2008},
  volume={53},
  pages={148-154}
}
N-Methyl-d-aspartate (NMDA) receptors play a critical role in the brain stimulating synaptic plasticity and mediating neurodegeneration; a neuroprotective role has also been described, but its molecular mechanisms in hippocampus are under study. Here, we report that in primary cultures of rat hippocampal neurons exposure to low micromolar NMDA concentrations are neuroprotective against excitotoxic insults, while high micromolar NMDA concentrations provoke neuronal death. Molecular analysis… CONTINUE READING
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