NMDA enhances a depolarization-activated inward current in subthalamic neurons

@article{Zhu2005NMDAEA,
  title={NMDA enhances a depolarization-activated inward current in subthalamic neurons},
  author={Zi-tao Zhu and Adam C Munhall and K Z Shen and Steven W. Johnson},
  journal={Neuropharmacology},
  year={2005},
  volume={49},
  pages={317-327}
}
Previous studies have shown that N-methyl-D-aspartate (NMDA) receptor stimulation evokes Ca2+- and Na+-dependent burst firing in subthalamic nucleus (STN) neurons. Using whole-cell patch pipettes to record currents under voltage-clamp, we identified a time-dependent depolarization-activated inward current (DIC) that may underlie NMDA-induced burst firing in STN neurons in rat brain slices. Continuous superfusion with NMDA (20 microM) elicited a marked TTX-insensitive inward current when the… CONTINUE READING

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