NMDA component in the effects of piracetam and new nootropic peptide GVS-111 on the neocortical and hippocampal EEG in conscious rats

@article{Kovalev2006NMDACI,
  title={NMDA component in the effects of piracetam and new nootropic peptide GVS-111 on the neocortical and hippocampal EEG in conscious rats},
  author={G. Kovalev and V. V. Vorob'ev and E. R. Akhmetova},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2006},
  volume={128},
  pages={822-825}
}
  • G. Kovalev, V. V. Vorob'ev, E. R. Akhmetova
  • Published 2006
  • Chemistry
  • Bulletin of Experimental Biology and Medicine
  • The effects of new nootropic dipeptide GVS-111 (N-phenylacetyl-L-prolylglycine ethyl ester) on EEG spectral characteristics were compared with those of piracetam. The EEG was recorded in the cortex and hippocampus of nonanesthetized nonrestrained rats with chronically implanted electrodes. GVS-111 and piracetam induced similar changes in EEG spectral profile in both structures increasing the α-band power and decreasing the power of the β-and δ-bands. These effects were prevented by… CONTINUE READING

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