NMDA channel regulation by channel-associated protein tyrosine kinase Src.

@article{Yu1997NMDACR,
  title={NMDA channel regulation by channel-associated protein tyrosine kinase Src.},
  author={Xiang Yu and Rand Askalan and G J Keil and Michael W. Salter},
  journal={Science},
  year={1997},
  volume={275 5300},
  pages={674-8}
}
The N-methyl-D-aspartate (NMDA) receptor mediates synaptic transmission and plasticity in the central nervous system (CNS) and is regulated by tyrosine phosphorylation. In membrane patches excised from mammalian central neurons, the endogenous tyrosine kinase Src was shown to regulate the activity of NMDA channels. The action of Src required a sequence [Src(40-58)] within the noncatalytic, unique domain of Src. In addition, Src coprecipitated with NMDA receptor proteins. Finally, endogenous Src… CONTINUE READING
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