NMDA antagonist properties of the putative antiaddictive drug, ibogaine.

  title={NMDA antagonist properties of the putative antiaddictive drug, ibogaine.},
  author={Piotr Popik and Richard T. Layer and Linda H. Fossom and Morris Benveniste and Beth Geter-Douglass and J. M. Witkin and Phil Skolnick},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={275 2},
Both anecdotal reports in humans and preclinical studies indicate that ibogaine interrupts addiction to a variety of abused substances including alcohol, opiates, nicotine and stimulants. Based on the similarity of these therapeutic claims to recent preclinical studies demonstrating that N-methyl-D-aspartate (NMDA) antagonists attenuate addiction-related phenomena, we examined the NMDA antagonist properties of ibogaine. Pharmacologically relevant concentrations of ibogaine produce a voltage… CONTINUE READING


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