NMDA and non-NMDA receptor-mediated differential Ca2+ load and greater vulnerability of motor neurons in spinal cord cultures

@article{Sen2008NMDAAN,
  title={NMDA and non-NMDA receptor-mediated differential Ca2+ load and greater vulnerability of motor neurons in spinal cord cultures},
  author={Indrani Sen and Dinesh C. Joshi and Preeti G. Joshi and Nanda B. Joshi},
  journal={Neurochemistry International},
  year={2008},
  volume={52},
  pages={247-255}
}
Glutamate receptor activated neuronal cell death has been implicated in the pathogenesis of motor neuron disease but the molecular mechanism responsible for neuronal dysfunction needs to be elucidated. In the present study, we examined the contribution of NMDA and non-NMDA sub-types of glutamate receptors in selective vulnerability of motor neurons. Glutamate receptor activated Ca2+ signaling, mitochondrial functions and neurotoxicity in motor neurons and other spinal neurons were studied in… CONTINUE READING
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