NMDA and GABAB (KIR) conductances: the "perfect couple" for bistability.

  title={NMDA and GABAB (KIR) conductances: the "perfect couple" for bistability.},
  author={Honi Sanders and Michiel Berends and Guy Major and Mark S. Goldman and John E. Lisman},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={33 2},
Networks that produce persistent firing in response to novel input patterns are thought to be important in working memory and other information storage functions. One possible mechanism for maintaining persistent firing is dendritic voltage bistability in which the depolarized state depends on the voltage dependence of the NMDA conductance at recurrent synapses. In previous models, the hyperpolarized state is dependent on voltage-independent conductances, including GABA(A). The interplay of… CONTINUE READING