NMDA Receptor Plasticity in the Hypothalamic Paraventricular Nucleus Contributes to the Elevated Blood Pressure Produced by Angiotensin II.

@article{Glass2015NMDARP,
  title={NMDA Receptor Plasticity in the Hypothalamic Paraventricular Nucleus Contributes to the Elevated Blood Pressure Produced by Angiotensin II.},
  author={Michael J. Glass and Gang Wang and Christal G Coleman and June Shu-Ling Chan and Evgeny Ogorodnik and Tracey A. Van Kempen and Teresa A Milner and Scott D Butler and Colin N Young and Robin L. Davisson and C Iadecola and Virginia M Pickel},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2015},
  volume={35 26},
  pages={9558-67}
}
Hypertension induced by angiotensin II (Ang II) is associated with glutamate-dependent dysregulation of the hypothalamic paraventricular nucleus (PVN). Many forms of glutamate-dependent plasticity are mediated by NMDA receptor GluN1 subunit expression and the distribution of functional receptor to the plasma membrane of dendrites. Here, we use a combined ultrastructural and functional analysis to examine the relationship between PVN NMDA receptors and the blood pressure increase induced by… CONTINUE READING