NMDA Receptor Expression in the Thalamus of the Stargazer Model of Absence Epilepsy

@inproceedings{Barad2017NMDARE,
  title={NMDA Receptor Expression in the Thalamus of the Stargazer Model of Absence Epilepsy},
  author={Zsuzsanna Barad and Dave R Grattan and Beulah Leitch},
  booktitle={Scientific reports},
  year={2017}
}
In the stargazer mouse model of absence epilepsy, altered corticothalamic excitation of reticular thalamic nucleus (RTN) neurons has been suggested to contribute to abnormal synchronicity in the corticothalamic-thalamocortical circuit, leading to spike-wave discharges, the hallmark of absence seizures. AMPA receptor expression and function are decreased in stargazer RTN, due to a mutation of AMPAR auxiliary subunit stargazin. It is unresolved and debated, however, if decreased excitation of RTN… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

References

Publications referenced by this paper.
Showing 1-10 of 82 references

Focus on epilepsy

  • H. Malkki
  • Nat . Neurosci .
  • 2015

Similar Papers

Loading similar papers…