NMDA-NR1 and -NR2B subunits mRNA expression in the hippocampus of rats tolerant to Diazepam.

@article{Prez2003NMDANR1A,
  title={NMDA-NR1 and -NR2B subunits mRNA expression in the hippocampus of rats tolerant to Diazepam.},
  author={Mariela Fernanda P{\'e}rez and Romina Salmir{\'o}n and Oscar A. Ramirez},
  journal={Behavioural brain research},
  year={2003},
  volume={144 1-2},
  pages={119-24}
}
The development of tolerance to the hypolocomotor effects of Diazepam (DZ) is thought to be a contingent or learning phenomenon. In previous reports, we demonstrated a positive correlation between the development of tolerance to the sedative effects of DZ and hippocampal synaptic plasticity. Furthermore, previous exposure to the drug administration context blocks both the tolerance to sedative effects of DZ and the increased hippocampal plasticity. The results of the present investigation show… CONTINUE READING

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