NMDA Channel Antagonist MK-801 Does Not Protect against Bilirubin Neurotoxicity

@article{Shapiro2007NMDACA,
  title={NMDA Channel Antagonist MK-801 Does Not Protect against Bilirubin Neurotoxicity},
  author={Steven M. Shapiro and Sompong Sombati and Angela S. Geiger and Ann C. Rice},
  journal={Neonatology},
  year={2007},
  volume={92},
  pages={248 - 257}
}
Background: Bilirubin encephalopathy or kernicterus is a potentially serious complication of neonatal hyperbilirubinemia. The mechanism of bilirubin-induced neurotoxicity is not known. Many neurological insults are mediated through NMDA receptor activation. Objective: We assessed the effect of the NMDA channel antagonist, MK-801 on bilirubin neurotoxicity in vivo and in vitro. Methods: Bilirubin toxic ity in vitro was assessed using trypan blue staining. Sulfadimethoxine injected (i.p… CONTINUE READING

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