NMD and microRNA expression profiling of the HPCX1 locus reveal MAGEC1 as a candidate prostate cancer predisposition gene

@inproceedings{Mattila2011NMDAM,
  title={NMD and microRNA expression profiling of the HPCX1 locus reveal MAGEC1 as a candidate prostate cancer predisposition gene},
  author={Henna Mattila and Martin Schindler and Jarkko Isotalo and Tarja Ikonen and Mauno Vihinen and Hannu Oja and Teuvo L. J. Tammela and Tiina A Wahlfors and Johanna Schleutker},
  booktitle={BMC Cancer},
  year={2011}
}
Several predisposition loci for hereditary prostate cancer (HPC) have been suggested, including HPCX1 at Xq27-q28, but due to the complex structure of the region, the susceptibility gene has not yet been identified. In this study, nonsense-mediated mRNA decay (NMD) inhibition was used for the discovery of truncating mutations. Six prostate cancer (PC) patients and their healthy brothers were selected from a group of HPCX1-linked families. Expression analyses were done using Agilent 44 K… CONTINUE READING
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