NM23-H1 tumor suppressor and its interacting partner STRAP activate p53 function.

@article{Jung2007NM23H1TS,
  title={NM23-H1 tumor suppressor and its interacting partner STRAP activate p53 function.},
  author={Haiyoung Jung and Hyun-A Seong and Hyunjung Ha},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 48},
  pages={35293-307}
}
p53 plays a critical role in a variety of growth inhibitory responses, including cell cycle arrest, differentiation, and apoptosis, and contributes to tumor suppression. Here we show that NM23-H1 and its binding partner STRAP (serine-threonine kinase receptor-associated protein) interact with p53 and potentiate p53 activity. Both NM23-H1 and STRAP directly interact with the central DNA binding domain within residues 113-290. The use of NM23-H1 and STRAP mutants revealed that Cys(145) of NM23-H1… CONTINUE READING

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