NLRs join TLRs as innate sensors of pathogens.

@article{Martinon2005NLRsJT,
  title={NLRs join TLRs as innate sensors of pathogens.},
  author={Fabio Martinon and J. -M. Tschopp},
  journal={Trends in immunology},
  year={2005},
  volume={26 8},
  pages={447-54}
}
Pathogen-recognition receptors (PRRs) are key components of immune systems and are involved in innate effector mechanisms and activation of adaptive immunity. Since their discovery in vertebrates, Toll-like receptors (TLRs) have become the focus of extensive research that has revealed their significance in the regulation of many facets of our immune system. What makes TLRs so central and fascinating is their ability to recognize microbes and directly initiate specific signal transduction… CONTINUE READING
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