NLRX1 alleviates lipopolysaccharide-induced apoptosis and inflammation in chondrocytes by suppressing the activation of NF-κB signaling.

@article{Ma2019NLRX1AL,
  title={NLRX1 alleviates lipopolysaccharide-induced apoptosis and inflammation in chondrocytes by suppressing the activation of NF-κB signaling.},
  author={Ding Ma and Yangxue Zhao and Jiang She and Yandong Zhu and Yu Fang Zhao and Liang Liu and Yingang Zhang},
  journal={International immunopharmacology},
  year={2019},
  volume={71},
  pages={
          7-13
        }
}
Osteoarthritis (OA) is a chronic debilitating disease characterized by joint degeneration. Excessive chondrocyte apoptosis and inflammation contributes to articular cartilage destruction in OA pathology. Nucleotide-binding oligomerization domain (NOD)-like receptor X1 (NLRX1) has emerged as a critical regulator of inflammation that participates in the pathology of diverse diseases. To date, little is known about the role of NLRX1 in OA. In the present study, we aimed to explore the function of… CONTINUE READING