NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses.

@article{Guo2016NLRX1SS,
  title={NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses.},
  author={Haitao Guo and Meng Deng and Maximilian Riess and Jinyao Mo and Lu Zhang and Alex S Petrucelli and Sunnie M. Yoh and Brice E. Barefoot and Melissa Samo and Gregory D Sempowski and A. Liangfu Zhang and Anamaris M. Colberg-Poley and Hui Feng and Stanley M Lemon and Yong Liu and Yanping Zhang and Haitao Wen and Zhigang Zhang and Blossom A Damania and Li-Chung Tsao and Qi Wang and Lishan Su and Joseph A Duncan and Sumit K. Chanda and Jenny P-Y Ting},
  journal={Cell host & microbe},
  year={2016},
  volume={19 4},
  pages={
          515-528
        }
}
Understanding the negative regulators of antiviral immune responses will be critical for advancing immune-modulated antiviral strategies. NLRX1, an NLR protein that negatively regulates innate immunity, was previously identified in an unbiased siRNA screen as required for HIV infection. We find that NLRX1 depletion results in impaired nuclear import of HIV-1 DNA in human monocytic cells. Additionally, NLRX1 was observed to reduce type-I interferon (IFN-I) and cytokines in response to HIV-1… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 22 CITATIONS

Regulating STING in health and disease

  • Journal of Inflammation
  • 2017
VIEW 17 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Rapid Inflammasome Activation following Mucosal SIV Infection of Rhesus Monkeys

Dan H Barouch, Khader Ghneim, +23 authors Rafick-Pierre Sekaly
  • Cell
  • 2016
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Similar Papers

Loading similar papers…