NLRP7 in the spectrum of reproductive wastage: rare non-synonymous variants confer genetic susceptibility to recurrent reproductive wastage.

@article{Messaed2011NLRP7IT,
  title={NLRP7 in the spectrum of reproductive wastage: rare non-synonymous variants confer genetic susceptibility to recurrent reproductive wastage.},
  author={Christiane Messaed and Wafaa Chebaro and Raphael B Di Roberto and C{\'e}cile Rittore and Annie Cheung and Jocelyne Arseneau and Ariel Schneider and Moy Fong Chen and Kurt Bernishke and Urvashi Surti and Lori Hoffner and Philippe G Sauthier and William M. Buckett and Jianhua Qian and Nga Man Lau and Rashmi Bagga and James C. Engert and Philippe Coullin and Isabelle Touitou and Rima Slim},
  journal={Journal of medical genetics},
  year={2011},
  volume={48 8},
  pages={540-8}
}
BACKGROUND NLRP7 mutations are responsible for recurrent molar pregnancies and associated reproductive wastage. To investigate the role of NLRP7 in sporadic moles and other forms of reproductive wastage, the authors sequenced this gene in a cohort of 135 patients with at least one hydatidiform mole or three spontaneous abortions; 115 of these were new patients. METHODS/RESULTS All mutations were reviewed and their number, nature and locations correlated with the reproductive outcomes of the… CONTINUE READING
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Genetic and epigenetic analysis of recurrent hydatidiform mole

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