NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

@article{Elinav2011NLRP6IR,
  title={NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis},
  author={Eran Elinav and Till Strowig and Andrew L. Kau and Jorge Henao-Mejia and Christoph A. Thaiss and Carmen J Booth and David R. Peaper and John Bertin and Stephanie C Eisenbarth and Jeffrey I. Gordon and Richard A Flavell},
  journal={Cell},
  year={2011},
  volume={145},
  pages={745-757}
}
Inflammasomes are multiprotein complexes that function as sensors of endogenous or exogenous damage-associated molecular patterns. Here, we show that deficiency of NLRP6 in mouse colonic epithelial cells results in reduced IL-18 levels and altered fecal microbiota characterized by expanded representation of the bacterial phyla Bacteroidetes (Prevotellaceae… CONTINUE READING
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