NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis.

  title={NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis.},
  author={Simon A Hirota and Jeffrey Ng and Alan Lueng and Maitham Khajah and Ken Parhar and Yan Li and Victor C K Lam and Mireille S Potentier and Kelvin Ng and Misha Bawa and Donna-Marie McCafferty and Kevin P. Rioux and Subrata Ghosh and Ramnik J. Xavier and Sean P Colgan and Jurg Tschopp and Daniel A Muruve and Justin A. MacDonald and Paul L. Beck},
  journal={Inflammatory bowel diseases},
  volume={17 6},
BACKGROUND Attenuated innate immune responses to the intestinal microbiota have been linked to the pathogenesis of Crohn's disease (CD). Recent genetic studies have revealed that hypofunctional mutations of NLRP3, a member of the NOD-like receptor (NLR) superfamily, are associated with an increased risk of developing CD. NLRP3 is a key component of the inflammasome, an intracellular danger sensor of the innate immune system. When activated, the inflammasome triggers caspase-1-dependent… CONTINUE READING


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[Inflammatory bowel diseases and inflammasome].

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi • 2011
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