NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

@article{Stutz2017NLRP3IA,
  title={NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain},
  author={Andrea Stutz and Carl Christian Kolbe and Rainer Stahl and Gabor L Horvath and Bernardo Simoes Franklin and Olivia van Ray and Rebecca Brinkschulte and Matthias Geyer and Felix Meissner and Eicke Latz},
  journal={The Journal of Experimental Medicine},
  year={2017},
  volume={214},
  pages={1725 - 1736}
}
NLRP3 is a cytosolic pattern recognition receptor that senses microbes and endogenous danger signals. Upon activation, NLRP3 forms an inflammasome with the adapter ASC, resulting in caspase-1 activation, release of proinflammatory cytokines and cell death. How NLRP3 activation is regulated by transcriptional and posttranslational mechanisms to prevent aberrant activation remains incompletely understood. Here, we identify three conserved phosphorylation sites in NLRP3 and demonstrate that NLRP3… 

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