NLRP3 inflammasome activation in Alzheimer's disease (INC9P.446)

  title={NLRP3 inflammasome activation in Alzheimer's disease (INC9P.446)},
  author={Te-Chen Tzeng and Douglas T Golenbock},
Neuroinflammation is now recognized as a fundamental response in Alzheimer’s pathology. Prominent activation of inflammatory responses has been observed in the brains of patients with Alzheimer’s disease, as well as in mouse models, however the role of neuroinflammation in Alzheimer’s disease pathogenesis is still not clear. We have reported that the fibrillar form of beta amyloid is capable of stimulating the production of the inflammatory cytokine IL-1β from microglia cells through the… CONTINUE READING

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