NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

@article{Doyle2012NLRP3HA,
  title={NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components},
  author={Sarah L Doyle and M. Campbell and E. Ozaki and R. G. Salomon and A. Mori and P. Kenna and G. Farrar and A. Kiang and M. Humphries and E. Lavelle and L. O’Neill and J. Hollyfield and P. Humphries},
  journal={Nature Medicine},
  year={2012},
  volume={18},
  pages={791-798}
}
Age-related macular degeneration (AMD) is the leading cause of central vision loss worldwide. Drusen accumulation is the major pathological hallmark common to both dry and wet AMD. Although activation of the immune system has been implicated in disease progression, the pathways involved are unclear. Here we show that drusen isolated from donor AMD eyes activates the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome, causing secretion of interleukin-1β (IL-1β) and IL-18… Expand
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