NLRP3 at the interface of metabolism and inflammation.

@article{Haneklaus2015NLRP3AT,
  title={NLRP3 at the interface of metabolism and inflammation.},
  author={Moritz Haneklaus and Luke A J O'Neill},
  journal={Immunological reviews},
  year={2015},
  volume={265 1},
  pages={53-62}
}
The discovery of the NLRP3 (NLR family, pyrin domain containing 3) inflammasome provided an important molecular mechanism in the induction of the central pro-inflammatory cytokine interleukin-1β (IL-1β), via activation of caspase-1, which processes pro-IL-1β into its mature active form. IL-1 has long been known to exert metabolic effects, most notably being implicated in insulin resistance and obesity. A key phenotype of the NLRP3-deficient mouse is insulin hypersensitivity. Over the past 5… CONTINUE READING
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