NLRP3 Inflammasome Activation by Paracoccidioides brasiliensis

  title={NLRP3 Inflammasome Activation by Paracoccidioides brasiliensis},
  author={Aldo Henrique F. P. Tavares and Kelly Grace Magalh{\~a}es and Raquel Almeida and Rafael Corr{\^e}a and Pedro Henrique Burgel and Anam{\'e}lia Lorenzetti Bocca},
  booktitle={PLoS neglected tropical diseases},
Paracoccidioides brasiliensis is the etiologic agent of paracoccidioidomycosis (PCM), the most prevalent systemic mycosis that is geographically confined to Latin America. The pro-inflammatory cytokine IL-1β that is mainly derived from the activation of the cytoplasmic multiprotein complex inflammasome is an essential host factor against opportunistic fungal infections; however, its role in infection with a primary fungal pathogen, such as P. brasiliensis, is not well understood. In this study… CONTINUE READING
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