NLRP1 influences the systemic sclerosis phenotype: a new clue for the contribution of innate immunity in systemic sclerosis-related fibrosing alveolitis pathogenesis.

@article{Dieud2011NLRP1IT,
  title={NLRP1 influences the systemic sclerosis phenotype: a new clue for the contribution of innate immunity in systemic sclerosis-related fibrosing alveolitis pathogenesis.},
  author={Philippe Dieud{\'e} and Micka{\"e}l Guedj and Julien Wipff and B{\'a}rbara Ruiz and Gabriela Riemekasten and Paolo Air{\'o} and Inga Melchers and {\'E}ric Hachulla and Marco Matucci Cerinic and Elisabeth Diot and Nicolas Hunzelmann and Paolo Caramaschi and Jean Sibilia and Kiet Phuong Tiev and Luc Mouthon and Valeria Riccieri and Jean Luc Cracowski and Patrick Henri Carpentier and Juergen Distler and Zahir Amoura and Ingo Helmut Tarner and J{\'e}r{\^o}me Avouac and Olivier Meyer and Andr{\'e} Kahan and Catherine Boileau and Yannick Allanore},
  journal={Annals of the rheumatic diseases},
  year={2011},
  volume={70 4},
  pages={668-74}
}
BACKGROUND Recent evidence has highlighted a potential role of interleukin 1β (IL-1β) in systemic sclerosis (SSc). NLRP1 provides a scaffold for the assembly of the inflammasome that promotes the processing and maturation of pro-IL-1β. In addition, NLRP1 variants were found to confer susceptibility to autoimmune disorders. OBJECTIVE /st> To study a possible association of the NLRP1 rs6502867, rs2670660 and rs8182352, rs12150220 and rs4790797 with SSc in the European Caucasian population… CONTINUE READING

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