NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8+ T cells

Abstract

Memory T cells exert antigen-independent effector functions, but how these responses are regulated is unclear. We discovered an in vivo link between flagellin-induced NLRC4 inflammasome activation in splenic dendritic cells (DCs) and host protective interferon-γ (IFN-γ) secretion by noncognate memory CD8+ T cells, which could be activated by Salmonella… (More)
DOI: 10.1038/ni.2195

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