NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition.

Abstract

The mechanistic target of rapamycin (mTOR) is a central cell growth controller and forms two distinct complexes: mTORC1 and mTORC2. mTORC1 integrates a wide range of upstream signals, both positive and negative, to regulate cell growth. Although mTORC1 activation by positive signals, such as growth factors and nutrients, has been extensively investigated… (More)
DOI: 10.1101/gad.265116.115

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Cite this paper

@article{Yuan2015NLKPR, title={NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition.}, author={Hai-Xin Yuan and Zhen Wang and Fa-xing Yu and Fulong Li and Ryan Charles Russell and Jenna L Jewell and Kun-Liang Guan}, journal={Genes & development}, year={2015}, volume={29 22}, pages={2362-76} }